Effectiveness of Chloroquine and hydroxychloroquine in treating selected patients with Sarcoidosis with neurological involvement
Identifieur interne : 002850 ( Main/Exploration ); précédent : 002849; suivant : 002851Effectiveness of Chloroquine and hydroxychloroquine in treating selected patients with Sarcoidosis with neurological involvement
Auteurs : O. P. Sharma [États-Unis]Source :
- Archives of neurology : (Chicago) [ 0003-9942 ] ; 1998.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antipaludiques (effets indésirables), Antipaludiques (usage thérapeutique), Chloroquine (effets indésirables), Chloroquine (usage thérapeutique), Encéphale (anatomopathologie), Femelle, Humains, Hydroxychloroquine (usage thérapeutique), Imagerie par résonance magnétique, Maladies du système nerveux (anatomopathologie), Maladies du système nerveux (traitement médicamenteux), Mâle, Résultat thérapeutique, Sarcoïdose (anatomopathologie), Sarcoïdose (traitement médicamenteux), Études rétrospectives.
- MESH :
- anatomopathologie : Encéphale, Maladies du système nerveux, Sarcoïdose.
- effets indésirables : Antipaludiques, Chloroquine.
- traitement médicamenteux : Maladies du système nerveux, Sarcoïdose.
- usage thérapeutique : Antipaludiques, Chloroquine, Hydroxychloroquine.
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Antimalarial, Antimalarials (adverse effects), Antimalarials (therapeutic use), Brain (pathology), Chemotherapy, Chloroquine, Chloroquine (adverse effects), Chloroquine (therapeutic use), Female, Human, Humans, Hydroxychloroquine, Hydroxychloroquine (therapeutic use), Magnetic Resonance Imaging, Male, Middle Aged, Nervous System Diseases (drug therapy), Nervous System Diseases (pathology), Nervous system diseases, Retrospective Studies, Sarcoidosis, Sarcoidosis (drug therapy), Sarcoidosis (pathology), Treatment, Treatment Outcome, Treatment efficiency.
- MESH :
- chemical , adverse effects : Antimalarials, Chloroquine.
- chemical , therapeutic use : Antimalarials, Chloroquine, Hydroxychloroquine.
- drug therapy : Nervous System Diseases, Sarcoidosis.
- pathology : Brain, Nervous System Diseases, Sarcoidosis.
- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Treatment Outcome.
Abstract
Objective: To assess the efficacy of chloroquine (Aralen) phosphate and hydroxychloroquine (Plaquenil) sulfate in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects. Design: Retrospective study. Setting: Sarcoidosis clinic at a university teaching hospital. Patients: Twelve patients with biopsy-proved sarcoidosis, 6 women and 6 men ranging from 20 to 49 years of age, with neurological involvement. Intervention: Chloroquine phosphate, 250 mg twice daily, or hydroxychloroquine sulfate, 200 mg twice daily, was administered for a period of 6 to 21 months. Patients had regular clinical evaluation, determination of serum and cerebrospinal fluid angiotensin-converting enzyme level, computed tomography or magnetic resonance imaging, chest radiography, lung function testing, and slit-lamp examination of the eyes. Results: Chloroquine or hydroxychloroquine either stabilized symptoms or controlled neurological symptoms in 10 of 12 patients. Two patients failed to respond. Cerebrospinal fluid abnormalities, including lymphocytosis, were seen in 3 patients. Magnetic resonance imaging with gadolinium was most helpful in supporting the diagnosis of sarcoidosis and monitoring the course of the disease. Conclusions: Chloroquine and hydroxychloroquine are effective in controlling neurological sarcoidosis in those patients who fail to respond to corticosteroids or develop severe side effects. Ocular toxic effects from chloroquine or hydroxychloroquine were not observed.
Affiliations:
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Le document en format XML
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P." last="Sharma">O. P. Sharma</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antimalarial</term><term>Antimalarials (adverse effects)</term><term>Antimalarials (therapeutic use)</term><term>Brain (pathology)</term><term>Chemotherapy</term><term>Chloroquine</term><term>Chloroquine (adverse effects)</term><term>Chloroquine (therapeutic use)</term><term>Female</term><term>Human</term><term>Humans</term><term>Hydroxychloroquine</term><term>Hydroxychloroquine (therapeutic use)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nervous System Diseases (drug therapy)</term><term>Nervous System Diseases (pathology)</term><term>Nervous system diseases</term><term>Retrospective Studies</term><term>Sarcoidosis</term><term>Sarcoidosis (drug therapy)</term><term>Sarcoidosis (pathology)</term><term>Treatment</term><term>Treatment Outcome</term><term>Treatment efficiency</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antipaludiques (effets indésirables)</term><term>Antipaludiques (usage thérapeutique)</term><term>Chloroquine (effets indésirables)</term><term>Chloroquine (usage thérapeutique)</term><term>Encéphale (anatomopathologie)</term><term>Femelle</term><term>Humains</term><term>Hydroxychloroquine (usage thérapeutique)</term><term>Imagerie par résonance magnétique</term><term>Maladies du système nerveux (anatomopathologie)</term><term>Maladies du système nerveux (traitement médicamenteux)</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sarcoïdose (anatomopathologie)</term><term>Sarcoïdose (traitement médicamenteux)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Maladies du système nerveux</term><term>Sarcoïdose</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Nervous System Diseases</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antipaludiques</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Nervous System Diseases</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies du système nerveux</term><term>Sarcoïdose</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antipaludiques</term><term>Chloroquine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sarcoïdose</term><term>Système nerveux pathologie</term><term>Chloroquine</term><term>Antipaludique</term><term>Hydroxychloroquine</term><term>Chimiothérapie</term><term>Traitement</term><term>Homme</term><term>Efficacité traitement</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To assess the efficacy of chloroquine (Aralen) phosphate and hydroxychloroquine (Plaquenil) sulfate in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects. Design: Retrospective study. Setting: Sarcoidosis clinic at a university teaching hospital. Patients: Twelve patients with biopsy-proved sarcoidosis, 6 women and 6 men ranging from 20 to 49 years of age, with neurological involvement. Intervention: Chloroquine phosphate, 250 mg twice daily, or hydroxychloroquine sulfate, 200 mg twice daily, was administered for a period of 6 to 21 months. Patients had regular clinical evaluation, determination of serum and cerebrospinal fluid angiotensin-converting enzyme level, computed tomography or magnetic resonance imaging, chest radiography, lung function testing, and slit-lamp examination of the eyes. Results: Chloroquine or hydroxychloroquine either stabilized symptoms or controlled neurological symptoms in 10 of 12 patients. Two patients failed to respond. Cerebrospinal fluid abnormalities, including lymphocytosis, were seen in 3 patients. Magnetic resonance imaging with gadolinium was most helpful in supporting the diagnosis of sarcoidosis and monitoring the course of the disease. Conclusions: Chloroquine and hydroxychloroquine are effective in controlling neurological sarcoidosis in those patients who fail to respond to corticosteroids or develop severe side effects. Ocular toxic effects from chloroquine or hydroxychloroquine were not observed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O. P." last="Sharma">O. P. Sharma</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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